In order to define clinical situations that require appropriate locoregional therapies and use the right approach, clinicians need to stay up-to-date on the updates as well as the controversies.

Few survivors meet all health behavior recommendations, and clinicians often report a lack of expertise, time, and resources to address healthy lifestyles with cancer survivors. Education on this topic can help clinicians encourage and support survivors to maintain and enhance their wellness.

With expanding treatment options, clinicians should understand important criteria used in selecting optimal first-and subsequent-line therapies for individuals with metastatic breast cancer. For clinicians, staying up to date with the available treatment options is important to integrate new evidence-based data into their clinical practice, and being familiar with the toxicity profiles is important to optimize patient outcomes.

Triple-negative breast cancer continues to be labeled with a poor prognosis secondary to the fact that it tends to be more aggressive and poses a greater risk of recurrence. Because it lacks the receptors that many drugs have been designed to target, the standard of practice remains chemotherapy. Therefore, research has been focused on trying to identify other therapeutic targets for which agents already exist or are currently being developed. Within recent years, PD-L1 inhibition is being studied in trials as a new avenue for treatment options in these patients. Current evidence demonstrates increased benefit when using these agents in combination with chemotherapy.