Bruton’s tyrosine kinase inhibitors (BTKi) have significantly changed the treatment landscape of B-cell malignancies. A thorough understanding of the mechanism of action (covalent vs. non-covalent), similarities and differences in their safety profile and management of specific treatment-related adverse events will enable clinicians to use these agents safely and effectively in routine clinical practice.

With improvement in treatment options and supportive care, patients with multiple myeloma (MM) are living longer. The majority of patients with MM are at risk for osteolytic bone lesions, osteoporosis, and infections among other complications. The outcomes of patients with MM can be improved by effective management of infections; recognizing and managing side effects of bone modifying therapy; and implementing plans of care to promote health, safety, mobility, and overall improved quality of life.

GvHD is a potentially serious complication that significantly impacts quality of life in patients undergoing allogeneic HCT. Treatment of GvHD can be optimized by providing coordinated care involving a multidisciplinary team preferably in medical centers which have access to specialized GvHD clinics. Oncology practitioners require ongoing education for the optimal management of patients with GvHD.

The treatment armamentarium for WM/LPL continues to grow, and the selection of therapy for initial management of patients with symptomatic WM depends on age, the severity of symptoms, presence of comorbidities, and patient preferences.