All patients experience some level of distress associated with a cancer diagnosis and the effects of the disease and its treatment regardless of the stage of disease. Clinically significant levels of distress occur in a subset of patients, and identification and treatment of distress are of utmost importance. These NCCN Guidelines Insights describe updates to the NCCN Distress Thermometer and Problem List, and to the treatment algorithms for patients with trauma- and stressor-related disorders.