The systemic therapy section of the NCCN Guidelines for Cervical Cancer has continuously added new therapy options over the past few years to reflect the new approvals. Knowledge in this topic will guide the practitioners in appropriately prioritizing these new treatment options to further improve patient outcomes.

Whole-brain radiation therapy was historically the mainstay of treatment for brain metastases but has fallen out of favor in clinical practice over the last several decades. Strategies to promote cognitive preservation in patients with brain metastases is an area of active investigation. Clinicians need to remain up to date on these strategies.

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer address all aspects of management for breast cancer. The treatment landscape of metastatic breast cancer is evolving constantly.

Targeting the anti-tumor immune response has become a widely used strategy for the therapy of patients with advanced solid tumors, but not all patients respond, and immune-related side effects plus the high cost of these therapies increase the need for effective biomarkers to ensure that the immune checkpoint inhibitors are used in patients with the best chance of success. Clinicians need to be aware of the assays that are most appropriate to use based on the tumor type and the pitfalls of each testing technology.