Application of Individualized Treatment for CLL/SLL: Novel Agents, Combinations, and Sequencing Therapy
The goal of this activity is to improve the competence and performance of learners to apply practice-changing clinical data and expert recommendations to optimize the use current/emerging therapeutic strategies in the care of their patients with CLL/SLL.
Provided by the National Comprehensive Cancer Network in partnership with Clinical Care Options, LLC
This program is intended for hematologists/oncologists, physician assistants, nurses, pharmacists, and other clinicians involved in the management of patients with chronic lymphocytic leukemia.
Upon completion of this activity, participants should be able to:
- Evaluate the efficacy and safety of targeted agents and combination regimens indicated for frontline therapy in CLL/SLL
- Select the optimal treatment for individual patients with newly diagnosed CLL/SLL based on the available clinical data, guidelines, and expert recommendations
- Apply the totality of clinical data to optimally sequence targeted therapies for the management of patients with CLL/SLL
- Develop an individualized treatment plan for patients with multiple relapses and resistance or intolerance to BTK inhibitors
- Evaluate the evolving role of allogeneic hematopoietic cell transplant and CAR T-cell therapy
- Develop strategies to address unique challenges (eg, identification and management of adverse events, adherence/compliance to treatment) as well as improve clinical outcomes and quality of life
William G. Wierda, MD, PhD
The University of Texas MD Anderson Cancer Center
Jeremy S. Abramson, MD, MMSc
Massachusetts General Hospital
Brian Hill, MD, PhD
Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute
NCCN Medical Education Disclosure Policy
It is the policy of NCCN that every 12 months, all faculty, moderators, activity planners and all internal planning staff participating in NCCN continuing education activities are expected to disclose any financial relationships with a commercial interest as defined by the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support. In addition, all faculty presentations have been reviewed for adherence to the ACCME’s Standards for Commercial Support (the provider develops activities/educational interventions independent of commercial interests [SCS 1, 2 and 6] by experts on the topics).
Per the ACCME Standards for Commercial Support, individuals who do not disclose relevant financial relationships will be disqualified from involvement in the CE activity as a content developer, planner, or presenter. A complete list of individuals’ relationships with external entities is available upon request.
NCCN continuing education considers financial relationships to create a “conflict of interest” when an individual has both a financial relationship with a commercial interest and the opportunity to affect CE content about the products or services of a commercial interest with which he/she and/or a spouse or partner has a financial relationship.
NCCN continuing education considers “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. NCCN does not set a minimal dollar amount for relationships to be significant. Inherent in any amount is the incentive to maintain or increase the value of the relationship.
All faculty for this continuing education activity are competent in the subject matter and qualified by experience, training, and/or preparation for the tasks and methods of delivery.
The faculty, NCCN staff, and CCO staff reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity.
The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME/CE activity:
Jeremy S. Abramson, MD, MMSc, has disclosed that he has received consulting fees from AbbVie, Allogene, AstraZeneca, BeiGene, C4 Therapeutics, Celgene, Incyte, Karyopharm, Kite, Morphosys, and Novartis.
Brian Hill, MD, PhD, has disclosed that he has received consulting fees and funds for research support from AbbVie, AstraZeneca, BeiGene, Genentech, and Pharmacyclics.
William G. Wierda, MD, PhD, has disclosed that he has received funds for research support from AbbVie, Acerta, Cyclacel, Genentech, Gilead Sciences, Janssen, Juno, Kite, Loxo, miRagen, Novartis, Oncternal, Pharmacyclics, Sunesis, and Xencor.
The activity planning staff listed below disclose no relevant financial relationships:
CCO: Bing-E Xu, PhD; Timothy A. Quill, PhD; Petra Cravens, PhD; Jason J. Everly, PharmD, BCOP, CHCP; Kevin Obholz, PhD
NCCN: Kristina M. Gregory, RN, MSN, OCN; Kristin Kline Hasson; Karen Kanefield; Kathy Ann Smith, CHCP
The CCO planning staff listed below discloses the following relevant financial relationships:
Jim Mortimer: spouse/partner has ownership interest (stock) in AstraZeneca
The NCCN clinical staff listed below discloses no relevant financial relationships:
Hema Sundar, PhD
Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. National Comprehensive Cancer Network® (NCCN®) and Clinical Care Options, LLC, do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of NCCN and Clinical Care Options, LLC. Please refer to the official prescribing information for each product for discussion of approved indication, contraindications, and warnings.
In support of improving patient care, National Comprehensive Cancer Network (NCCN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
NCCN designates this live activity for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
NCCN designates this educational activity for a maximum of 2.0 contact hours.
NCCN designates this application-based continuing education activity for 2.0 contact hours (0.2 CEUs) of continuing education credit. UAN: JA4008196-0000-20-099-L01-P
NCCN has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 2.0 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.
- 2.00 AAPA Category 1 CME credit
- 2.00 ACPE contact hours
- 2.00 AMA PRA Category 1 Credit™
- 2.00 ANCC contact hours
- 2.00 Participation