Immunotherapy using antibody drug conjugates, immune check point inhibitors, and chimeric antigen receptor (CAR) T-cells has significantly transformed the treatment landscape of relapsed or refractory hematologic malignancies.

Multiple CAR T-cell therapies are approved for the treatment of certain relapsed or refractory hematologic malignancies with promising clinical outcomes. However, treatment with CAR T-cell therapy is not without risk and can result in severe and potentially fatal toxicities.

Cellular therapies are associated with an increased infection risk, and vaccination in these survivors plays a critical role in lowering that risk. Clinicians need to be educated on the importance of vaccination in these survivors as well as the details of dosing and timing of vaccines to best protect this vulnerable population from vaccine-preventable diseases.
The NCCN 2022 Annual Congress: Hematologic Malignancies™ will focus on updates to the NCCN Guidelines®, new, emerging and novel therapeutic agents, advances in cancer care, and the practical management of patients with hematologic malignancies, as well as re-vaccination of patients with hematologic malignancies and hematopoietic growth factors.
It is integral for nurses to have current knowledge of new targeted therapies in hematologic malignancies to understand mechanisms of actions and side effect profiles to support optimal patient outcomes.
That patients’ signs and symptoms are often nonspecific can lead to delays in diagnosis and treatment of histiocytic disorders, and ambiguous cases should be evaluated at centers of expertise. Although challenging, it is important that clinicians remain current with advances in the management of these disorders.

The management of cancer is constantly evolving through the introduction of new developments related to cancer treatment and supportive care. This program will provide hematology/oncology nurses with comprehensive and clinically relevant information to optimize patient education and care.

CAR T-cell therapy is associated with a novel toxicity profile with complex monitoring and supportive care requirements.

TLS is a potentially serious complication of anticancer therapy. If left untreated, its progression may cause acute kidney failure, cardiac arrhythmias, seizures, loss of muscle control, and death.

Nurse practitioners and other health care providers play a critical role in the recognition and management of cancer-related infections.

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