Optimizing Neoadjuvant Therapy of Rectal Cancer With Oxaliplatin

Neoadjuvant chemoradiation (CRT) is standard treatment for stage II–III rectal cancer. Fluoropyrimidine-based CRT prolongs disease-free survival over adjuvant CRT and improves local control over both adjuvant CRT and neoadjuvant radiotherapy alone, but does not prolong overall survival. New approaches to neoadjuvant therapy may improve outcome in this disease. Oxaliplatin, a standard component of chemotherapy for the treatment of both resected and metastatic colon cancer, is a potent radiosensitizer with synergistic radiosensitizing activity in combination with 5-FU in preclinical studies. Early clinical trials showed promising activity with the addition oxaliplatin to 5-FU–based CRT in stage II–III rectal cancer; however, early data from phase III trials seem to be disappointing. This article reviews the existing literature and explores the potential role of oxaliplatin as part of neoadjuvant CRT for rectal cancer.

Target Audience

This activity has been designated to meet the educational needs of physicians and nurses involved in the management of patients with cancer.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Describe the role of oxaliplatin in the management of rectal cancer
  • Describe the benefits and limitations of oxaliplatin in the neoadjuvant treatment of localized rectal cancer
Additional information
Supporters: 

No commercial support was received for this article.

Course summary
Available credit: 
  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Physician
Course opens: 
03/15/2013
Course expires: 
03/15/2014
Cost:
$0.00

Ludmila Katherine Martin, MD
Department of Internal Medicine, Division of Medical Oncology, Section of Gastrointestinal Oncology
The Ohio State University Medical Center
Columbus, Ohio

Tanios Bekaii-Saab, MD
Department of Internal Medicine, Division of Medical Oncology, Section of Gastrointestinal Oncology
The Ohio State University Medical Center
Columbus, Ohio

Available Credit

  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Physician

Accreditation Period

Course opens: 
03/15/2013
Course expires: 
03/15/2014

Price

Cost:
$0.00
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