Successful Resection After Neoadjuvant Therapy in Pancreatic Adenocarcinoma

A 59-year-old woman presented with borderline resectable pancreatic adenocarcinoma involving the neck and body of the pancreas. She was treated with systemic chemotherapy followed by chemoradiation, with subsequent downstaging of the tumor by imaging. Subsequent resection had negative margins and negative lymph nodes with only microscopic disease present in the tumor specimen. Neoadjuvant therapy is controversial but could play a role in borderline resectable disease by allowing for higher chance of negative margins at surgery and increasing the chance for cure in these patients. Microscopic disease at time of resection is rare.

Target Audience

This activity has been designed to meet the educational needs of physicians and nurses involved in the management of patients with cancer.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Describe the rationale for the management methods used in this case presentation
  • Describe the ideal management of a patient with borderline resectable disease
Additional information
Supporters: 

No commercial support was received for this article.

Course summary
Available credit: 
  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Physician
Course opens: 
11/01/2012
Course expires: 
11/01/2013
Cost:
$0.00

Parvin F. Peddi, MD
Division of Oncology, Washington University School of Medicine
St. Louis, Missouri

Andrea Wang-Gillam, MD, PhD
Division of Oncology, Washington University School of Medicine
St. Louis, Missouri

Available Credit

  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Physician

Accreditation Period

Course opens: 
11/01/2012
Course expires: 
11/01/2013

Price

Cost:
$0.00
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