Hepatic Epithelioid Hemangioendothelioma in a Patient With Hemochromatosis

Hepatic epithelioid hemangioendothelioma (HEHE) is a rare hepatic vascular tumor that represents a diagnostic challenge. The rarity of this neoplasm precludes establishment of a standard-ofcare treatment. Risk factors for HEHE are not well-known. Liver transplant remains the most common therapeutic modality for nonmetastatic disease. This article describes a patient who presented with abdominal pain, fatigue, poor appetite, and weight loss. Genetic testing showed that the patient was homozygous for C282Y consistent with hereditary hemochromatosis, and liver biopsy was consistent with malignant epithelioid hemangioendothelioma. The patient was referred for a liver transplant but was deemed inappropriate for transplant secondary to peritoneal studding, with frozen-section analysis showing metastatic disease at the time of surgery.

Target Audience

This activity has been designated to meet the educational needs of physicians and nurses involved in the management of patients with cancer.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Recognize the clinical manifestations of HEHE
  • Discuss potential treatment options for HEHE
Additional information
Supporters: 

No commercial support was received for this article.

Course summary
Available credit: 
  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Physician
Course opens: 
09/05/2014
Course expires: 
09/05/2015
Cost:
$0.00
Nisar Ahmad, MD
Department of Internal Medicine
University of Cincinnati College of Medicine
Cincinnati, Ohio
Rajan Prakash, MD
Department of Internal Medicine
University of Cincinnati College of Medicine
Cincinnati, Ohio
Denise M. Adams, MD
Division of Hematology Oncology
UC Department of Pediatrics
Cincinnati Children’s Hospital
Cincinnati, Ohio
Nagla Abdel Karim, MD, PhD
Division of Hematology and Oncology
University of Cincinnati College of Medicine
Cincinnati, Ohio
Jiang Wang, MD, PhD
Division of Pathology
University of Cincinnati College of Medicine
Cincinnati, Ohio
 

Available Credit

  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Physician

Accreditation Period

Course opens: 
09/05/2014
Course expires: 
09/05/2015

Price

Cost:
$0.00
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  • A device with an Internet connection
  • Adobe Reader or other PDF reader software for article and certificate viewing/printing