Hepatic Epithelioid Hemangioendothelioma in a Patient With Hemochromatosis
Hepatic epithelioid hemangioendothelioma (HEHE) is a rare hepatic vascular tumor that represents a diagnostic challenge. The rarity of this neoplasm precludes establishment of a standard-ofcare treatment. Risk factors for HEHE are not well-known. Liver transplant remains the most common therapeutic modality for nonmetastatic disease. This article describes a patient who presented with abdominal pain, fatigue, poor appetite, and weight loss. Genetic testing showed that the patient was homozygous for C282Y consistent with hereditary hemochromatosis, and liver biopsy was consistent with malignant epithelioid hemangioendothelioma. The patient was referred for a liver transplant but was deemed inappropriate for transplant secondary to peritoneal studding, with frozen-section analysis showing metastatic disease at the time of surgery.
Target Audience
This activity has been designated to meet the educational needs of physicians and nurses involved in the management of patients with cancer.
Learning Objectives
Upon completion of this activity, participants will be able to:
- Recognize the clinical manifestations of HEHE
- Discuss potential treatment options for HEHE
Nisar Ahmad, MD Department of Internal Medicine University of Cincinnati College of Medicine Cincinnati, Ohio | Rajan Prakash, MD Department of Internal Medicine University of Cincinnati College of Medicine Cincinnati, Ohio |
Denise M. Adams, MD Division of Hematology Oncology UC Department of Pediatrics Cincinnati Children’s Hospital Cincinnati, Ohio | Nagla Abdel Karim, MD, PhD Division of Hematology and Oncology University of Cincinnati College of Medicine Cincinnati, Ohio |
Jiang Wang, MD, PhD Division of Pathology University of Cincinnati College of Medicine Cincinnati, Ohio |
Available Credit
- 1.00 Participation
- 1.00 Nurse
- 1.00 Physician
Price
Required Hardware/software
To access this activity, users will need:
- A device with an Internet connection
- Adobe Reader or other PDF reader software for article and certificate viewing/printing