New Meets Old: A Case Study and Review of Novel Therapeutics for the Treatment of CLL in Older Patients

The treatment of older or medically frail patients with chronic lymphocytic leukemia (CLL) presents unique challenges to clinicians attempting to maximize efficacy while avoiding significant toxicity. This case report presents a 75-year-old man with Rai stage II CLL complicated by massive splenomegaly, high-risk cytogenetics, and intolerance to first-line therapy recommended by the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non-Hodgkin’s Lymphomas. A brief summary of his disease and treatment course accompanies a discussion of the special challenges associated with treating this patient population. In addition, emerging novel and targeted therapies, including next-generation monoclonal antibodies and small molecule inhibitors, are reviewed in the broader context of evolving standards of care and the NCCN Guidelines.

Target Audience

This activity has been designated to meet the educational needs of physicians and nurses involved in the management of patients with cancer.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • List contributing factors that can complicate the decisionmaking process for the treatment of older or medically frail “unfit” patients with CLL
  • Discuss the risks and benefits of emerging therapeutic options for the treatment of older patients with CLL
Additional information
Supporters: 

No commercial support was received for this article.

Course summary
Available credit: 
  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Physician
Course opens: 
10/13/2014
Course expires: 
10/13/2015
Cost:
$0.00

Neel K. Gupta, MD
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California

Charalambos Andreadis, MD, MSCE
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California

Available Credit

  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Physician

Accreditation Period

Course opens: 
10/13/2014
Course expires: 
10/13/2015

Price

Cost:
$0.00
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Required Hardware/software

To access this activity, users will need:

  • A device with an Internet connection
  • Adobe Reader or other PDF reader software for article and certificate viewing/printing