Cotreatment of Hairy Cell Leukemia and Melanoma With the BRAF Inhibitor Dabrafenib

The activating BRAF mutation p.V600E has been identified in many cancers, including colon and lung adenocarcinoma, papillary thyroid cancer, malignant melanoma, and hairy cell leukemia (HCL). Malignant melanoma and HCL are of particular interest because of both the high proportion of cases harboring the mutation and the dramatic responses to BRAF inhibitor therapy reported in the literature. This report presents a patient with HCL and malignant melanoma with the BRAF V600E mutation, and discusses the successful treatment of both cancers with the BRAF inhibitor dabrafenib.

Target Audience

This activity has been designated to meet the educational needs of physicians and nurses involved in the management of patients with cancer.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Explain the potential benefit of utilizing a single BRAF inhibitor to treat a patient with multiple BRAF-mutated malignancies
Additional information
Supporters: 

No commercial support was received for this article.

Course summary
Available credit: 
  • 0.50 Participation
  • 0.50 Nurse
  • 0.50 Physician
Course opens: 
01/01/2015
Course expires: 
12/31/2015
Cost:
$0.00
James S. Blachly, MD
Division of Hematology, Department of Internal Medicine
The Ohio State University
Columbus, Ohio
Gerard Lozanski, MD
Department of Pathology
The Ohio State University
Columbus, Ohio
David M. Lucas, PhD
Division of Hematology, Department of Internal Medicine
The Ohio State University
Columbus, Ohio
Michael R. Grever, MD
Division of Hematology, Department of Internal Medicine
The Ohio State University
Columbus, Ohio
Kari Kendra, MD, PhD
Division of Oncology
The Ohio State University
Columbus, Ohio
Leslie A. Andritsos, MD
Division of Hematology, Department of Internal Medicine
The Ohio State University
Columbus, Ohio

Available Credit

  • 0.50 Participation
  • 0.50 Nurse
  • 0.50 Physician

Accreditation Period

Course opens: 
01/01/2015
Course expires: 
12/31/2015

Price

Cost:
$0.00
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Required Hardware/software

To access this activity, users will need:

  • A device with an Internet connection
  • Adobe Reader or other PDF reader software for article and certificate viewing/printing