Metastatic Insulinoma: Current Molecular and Cytotoxic Therapeutic Approaches for Metastatic Well-Differentiated panNETs

Pancreatic neuroendocrine tumors (panNETs) are a type of neuroendocrine tumor with 5-year overall survival rates of approximately 50% when metastasis is present at diagnosis. Tumor grade, as defined by Ki-67 proliferation index, influences overall survival, with low-grade tumors portending a better outcome than intermediate- and high-grade tumors. This case report follows the clinical course and management of a patient with an insulin-secreting metastatic panNET who died 10 years after diagnosis after a treatment course with regional therapy and multiple forms of cytotoxic and molecularly targeted agents. This report presents the various treatment options available for patients with insulin-secreting metastatic panNETs.

Target Audience

This activity has been designated to meet the educational needs of physicians and nurses involved in the management of patients with cancer.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Assess the various treatment options available for patients with insulin secreting metastatic panNETs including regional therapy, systemic cytotoxic therapy, and systemic targeted therapy
  • Discuss the challenges of symptom management in patients with metastatic insulinoma
Additional information

No commercial support was received for this article.

Course summary
Available credit: 
  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Physician
Course opens: 
Course expires: 

Iulia Giuroiu, MD
Division of Hematology/Oncology
Laura and Isaac Perlmutter Cancer Center
New York University Langone Medical Center
New York, New York

Diane Reidy-Lagunes, MD, MS
Division of Solid Tumor Oncology, Gastrointestinal Oncology Service
Department of Medicine, Memorial Sloan Kettering Cancer Center
Weill College of Medicine, Cornell University
New York, New York

Available Credit

  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Physician


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Required Hardware/software

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  • A device with an Internet connection
  • Adobe Reader or other PDF reader software for article and certificate viewing/printing