Monthly Oncology Tumor Boards: A Multidisciplinary Approach to Individualized Patient Care - Kidney Cancer

March 30, 2015

Join Steven Chang, MD and Toni Choueiri, MD as they present their multidisciplinary expertise on a range of cases pertaining to kidney cancer.

To date, seven such agents have been approved by the FDA for the first- and second-line treatment of advanced RCC: sunitinib malate, sorafenib tosylate, temsirolimus, everolimus, bevacizumab in combination with interferon, pazopanib, and axitinib. This has led to a paradigm shift of treatment of kidney cancer from cytokine immunotherapy to targeted therapy and has significantly improved patient survival rates.
Prior to therapy selection, the patients are stratified in risks groups.  The most widely used prognostic factor model is from the Memorial Sloan-Kettering Cancer Center (MSKCC). However, the MSKCC prognostic risk profiles are derived from the era of immunotherapy and limited to a population of patients eligible for participation in immunotherapy clinical trials. A new prognostic model for patients with advanced RCC treated with VEGF-targeted therapy has recently been developed and validated known as the International Metastatic RCC Database Consortium or Heng’s model.

All patients with advanced RCC require best supportive care and advances have been in this area as well. Strategies have been developed to enhance tolerability of the targeted agents including dose reductions, schedule changes or alternative therapies. Progression/relapse and the need for subsequent lines therapy in patients with RCC are nearly universal. Sequencing the appropriate therapy for maximum benefit is critical.

Despite the advances, the newer therapies have not yielded a long-term solution for patients. The American Cancer Society estimates over 63,920 Americans will be diagnosed with kidney cancer in 2014 and over 13,860 will die of the disease. Majority of patients are diagnosed with locally advanced or metastatic disease.  The 5-year survival rate is still dismal, in the order of 10%. New drugs with novel mechanism of action (e.g., denosumab) are available for treatment of metastatic bone disease. New agents are currently being studied as adjuvant, first- and subsequent line therapy options  including the use of the currently approved targeted therapy in the adjuvant setting.

Target Audience

This educational activity is designed to meet the educational needs of oncologists, pathologists, nurses, pharmacists, and other health care professionals who manage patients with cancer.

Learning Objectives

Following this activity, participants should be able to:

  • Apply NCCN Guideline-based therapeutic strategies for the treatment of patients with kidney cancer
  • Describe the multidisciplinary aspects of the management of patients with kidney cancer
  • Identify the key characteristics of  kidney cancer that trigger decision points
  • Recognize situations where optimal care may require adapting the Guideline recommendations to individual circumstances
Additional information

Supported by educational grants from:

  • AstraZeneca
  • Exelixis Inc.
  • Genentech BioOncology
  • Janssen Biotech, Inc.
  • Novartis Oncology
  • Takeda Oncology

Supported by a grant from Onyx Pharmaceuticals.

Supported by independent educational grants from Merck and Prometheus Laboratories Inc.

Supported by an unrestricted, educational grant from Celgene Corporation.

Course summary
Available credit: 
  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Pharmacist
  • 1.00 Physician
Course opens: 
Course expires: 
Event starts: 
03/30/2015 - 2:00pm EDT
Event ends: 
03/30/2015 - 3:00pm EDT

Steven Chang, MD
Dana-Farber/Brigham and Women's Cancer Center | Massachusetts General Hospital Cancer Center

Toni Choueiri, MD
Dana-Farber/Brigham and Women's Cancer Center | Massachusetts General Hospital Cancer Center

This activity is approved for AMA PRA Category 1 Credit(s)™. Nursing and pharmacy (ACPE) credits are also provided. View complete accreditation information

Available Credit

  • 1.00 Participation
  • 1.00 Nurse
  • 1.00 Pharmacist
  • 1.00 Physician


Please login or register to take this course.

Required Hardware/software

To complete this activity, users will need:

  • A device with an Internet connection and sound playback capability
  • Adobe Reader or other PDF reader software for certificate viewing/printing