Practical Use of Next Generation Sequencing in Metastatic Disease
Next generation sequencing methods are increasingly being utilized to match patients with targeted therapies. Practitioners need to know the types of genetic alterations that can be detected, the different technologies that are described as “next-generation sequencing”, and the limitations of those techniques in order to ensure that their patients can be matched with appropriate targeted therapies or recommended for appropriate clinical trials in the metastatic setting.
This educational program is designed to meet the educational needs of physicians, nurses, physician assistants, pharmacists, and other health care professionals who manage patients with cancer.
Following this program, participants should be able to:
- Describe three barriers to broadly adopting next generation sequencing for patients with metastatic disease
- Outline methods to circumvent at least one of these barriers
- Describe the different types of testing that comprise next generation sequencing, and discuss the benefits and drawbacks of each for identifying particular actionable molecular abnormalities
Razelle Kurzrock, MD
UC San Diego Moores Cancer Center
NCCN Medical Education Disclosure Policy
It is the policy of NCCN that every 12 months, all faculty, moderators, activity planners and all internal planning staff participating in NCCN continuing education activities are expected to disclose any financial relationships with a commercial interest as defined by the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support. In addition, all faculty presentations have been reviewed for adherence to the ACCME’s Standards for Commercial Support (the provider develops activities/educational interventions independent of commercial interests [SCS 1, 2 and 6] by experts on the topics).
Per the ACCME Standards for Commercial Support, individuals who do not disclose relevant financial relationships will be disqualified from involvement in the CE activity as a content developer, planner, or presenter. A complete list of individuals’ relationships with external entities is available upon request.
NCCN continuing education considers financial relationships to create a “conflict of interest” when an individual has both a financial relationship with a commercial interest and the opportunity to affect CE content about the products or services of a commercial interest with which he/she and/or a spouse or partner has a financial relationship.
NCCN continuing education considers “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. NCCN does not set a minimal dollar amount for relationships to be significant. Inherent in any amount is the incentive to maintain or increase the value of the relationship.
All faculty for this continuing education activity are competent in the subject matter and qualified by experience, training, and/or preparation for the tasks and methods of delivery.
Faculty presentations may include discussion of off-label use. Faculty will disclose that the use in question is not currently approved by the FDA per the product labeling.
The faculty listed below discloses the following relevant financial relationships:
Razelle Kurzrock, MD
Actuate Therapeutics: Consulting Fees; Scientific Advisor
Boerhringer Ingelheim GmbH: Grant/Research Support
CureMatch, Inc.: Equity Interests/Stock Options; Officer, Director or any other fiduciary role
CureMetrix, Inc.: Officer, Director or any other fiduciary role
DeBiopharm Group: Grant/Research Support
Gaido Health: Consulting Fees; Scientific Advisor
Genentech, Inc.: Grant/Research Support
Grifols: Grant/Research Support
Guardant Health, Inc.: Grant/Research Support
Foundation Medicine: Grant/Research Support
Incyte Corporation: Grant/Research Support
IDbyDNA, Inc.: Equity Interests/Stock Options
Konica Minolta: Grant/Research Support
Loxo Oncology, Inc.: Consulting Fees; Scientific Advisor
NeoMed: Consulting Fees; Scientific Advisor
Merck & Co., Inc.: Consulting Fees; Scientific Advisor
Merck Serono: Grant/Research Support
OmniSeq: Grant/Research Support
Pfizer, Inc.: Consulting Fees; Scientific Advisor; Grant/Research Support
Roche Laboratories, Inc.: Consulting Fees; Scientific Advisor; Honoraria
Sequenom: Grant/Research Support
Soluventis Nanotherapeutics: Equity Interests/Stock Options; Consulting Fees; Scientific Advisor
XBiotech: Consulting Fees; Scientific Advisor
NCCN Staff Disclosures
The NCCN Activity Planning staff listed below discloses no relevant financial relationships:
Robert W. Carlson, MD; Melissa Esplen; Mark A. Geisler; Kristina M. Gregory, RN, MSN, OCN; Kristin Kline Hasson; Rose Joyce; Karen Kanefield; Wui-Jin Koh, MD; Lisa Perfidio, MS; Kathy Ann Smith, CHCP; Sarah Weinstein; Gary J. Weyhmuller, MBA, SPHR
The NCCN Clinical staff listed below below discloses no relevant financial relationships:
Mary Anne Bergman; Jennifer L. Burns, BS; Susan D. Darlow, PhD; Mary A. Dwyer, MS, CGC; Anita M. Engh, PhD; Ellen Erkess; Deborah A. Freedman-Cass, PhD; Lisa Gurski, PhD; Miranda Hughes, PhD; Alyse Johnson-Chilla; Rashmi Kumar, PhD; Nicole R. McMillian, MS, CHES; Ndiya Ogba, PhD; Lenora Pluchino, PhD; Jillian Scavone, PhD; Dorothy A. Shead, MS; Hema Sundar, PhD
The NCCN Clinical staff listed below below discloses the following relevant financial relationships:
Griselda Zuccarino-Catania, PhD
Janssen Pharmaceutical Products, LP: Salary*
In support of improving patient care, National Comprehensive Cancer Network (NCCN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
NCCN designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
NCCN designates this educational activity for a maximum of 0.50 contact hour.
NCCN designates this knowledge-based continuing education activity for 0.50 contact hour (0.05 CEUs) of continuing education credit. UAN: JA4008196-0000-20-052-H01-P
NCCN has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.50 AAPA Category 1 CME credits. Approval is valid until 3/1/2021. PAs should only claim credit commensurate with the extent of their participation.
- 0.50 AAPA Category 1 CME credit
- 0.50 ACPE contact hours
- 0.50 AMA PRA Category 1 Credit™
- 0.50 ANCC contact hours
- 0.50 Participation
To complete this activity, users will need:
- A device with an Internet connection
- One of the two latest versions of Google Chrome, Mozilla Firefox, or Safari (Internet Explorer is no longer supported)
- Adobe Flash Player and/or an HTML5 capable browser for video or audio playback
- Adobe Reader or other PDF reader software for certificate viewing/printing