Controversies in the Management of Early-Stage Hodgkin Lymphoma
Patients with early-stage Hodgkin lymphoma (HL) often experience high cure rates with current therapeutic measures which include chemotherapy alone or chemotherapy and radiotherapy; however, late effects due to treatment-related toxicity is of significant concern. To minimize the exposure of patients to therapy, some strategies include omitting radiotherapy or using positron emission tomography to aid in response-adapted therapy. Some challenges with these strategies are that omitting radiotherapy may minimize some treatment-related toxicity, but lead to some increases in recurrence. In terms of response-adapted therapy, there is a need to harmonize the measures used to assess disease response to treatment (e.g., Deauville score). Emerging studies are shedding light on these controversies and clinicians are challenged to remain abreast of these developments to optimize treatment of patients with early-stage HL.
This information was originally presented at the NCCN 2020 Virtual Congress: Hematologic Malignancies™ held on October 9-10, 2020.
This educational program is designed to meet the educational needs of oncologists, hematologists, nurse practitioners, nurses, pharmacists, physician assistants, and other health care professionals who manage patients with hematologic malignancies.
Following this program, participants should be able to:
- Summarize current treatment strategies for early-stage Hodgkin lymphoma (HL).
- Define key controversies associated with response-adapted therapy in the management of early-stage HL.
- Compare and contrast novel or emerging treatment approaches for early-stage HL.
Ranjana H. Advani, MD
Stanford Cancer Institute
NCCN Medical Education Disclosure Policy
It is the policy of NCCN that every 12 months, all faculty, moderators, activity planners and all internal planning staff participating in NCCN continuing education activities are expected to disclose any financial relationships with a commercial interest as defined by the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support. In addition, all faculty presentations have been reviewed for adherence to the ACCME’s Standards for Commercial Support (the provider develops activities/educational interventions independent of commercial interests [SCS 1, 2 and 6] by experts on the topics).
Per the ACCME Standards for Commercial Support, individuals who do not disclose relevant financial relationships will be disqualified from involvement in the CE activity as a content developer, planner, or presenter. A complete list of individuals’ relationships with external entities is available upon request.
NCCN continuing education considers financial relationships to create a “conflict of interest” when an individual has both a financial relationship with a commercial interest and the opportunity to affect CE content about the products or services of a commercial interest with which he/she and/or a spouse or partner has a financial relationship.
NCCN continuing education considers “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. NCCN does not set a minimal dollar amount for relationships to be significant. Inherent in any amount is the incentive to maintain or increase the value of the relationship.
All faculty for this continuing education activity are competent in the subject matter and qualified by experience, training, and/or preparation for the tasks and methods of delivery.
Faculty presentations may include discussion of off-label use. Faculty will disclose that the use in question is not currently approved by the FDA per the product labeling.
The faculty listed below discloses the following relevant financial relationships:
Ranjana H. Advani, MD
ADC Therapeutics: Consulting Fee
Celgene Corporation: Consulting Fee
Forty Seven, Inc.: Grant/Research Support
Genentech, Inc./Roche Laboratories, Inc.: Consulting Fee; Grant/Research Support; Scientific Advisor
Gilead Sciences, Inc.: Consulting Fee; Grant/Research Support; Scientific Advisor
Janssen Pharmaceutica Products, LP: Grant/Research Support
Kura Oncology, Inc.: Grant/Research Support
Merck & Co., Inc.: Grant/Research Support
Millennium Pharmaceuticals, Inc.: Grant/Research Support
Portola Pharmaceuticals, Inc.: Consulting Fee
Regeneron Pharmaceuticals, Inc.: Grant/Research Support
sanofi-aventis U.S.: Consulting Fee
Seattle Genetics, Inc.: Consulting Fee; Grant/Research Support; Scientific Advisor
Takeda Pharmaceuticals North America, Inc.: Consulting Fee; Scientific Advisor
NCCN Staff Disclosures
The NCCN Activity Planning staff listed below discloses no relevant financial relationships:
Michael Abrams; Melissa Esplen; Mark A. Geisler; Kristina M. Gregory, RN, MSN, OCN; Kristin Kline Hasson; Rose Joyce; Karen Kanefield; Lisa Perfidio, MS; Shannon Ryan, CMP; Kathy Ann Smith, CHCP; Sarah Weinstein
The NCCN Leadership listed below discloses no relevant financial relationships:
Robert W. Carlson, MD; Gary J. Weyhmuller, MBA, SPHR
The NCCN Leadership listed below discloses the following relevant financial relationships:
Wui-Jin Koh, MD: IBM Watson Health for Oncology and Genomics; Scientific Advisor
The NCCN Clinical staff listed below discloses no relevant financial relationships:
Jennifer L. Burns, BS; Ndiya Ogba, PhD
In support of improving patient care, National Comprehensive Cancer Network (NCCN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
NCCN designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
NCCN designates this educational activity for a maximum of 0.50 contact hour.
NCCN designates this knowledge-based continuing education activity for 0.50 contact hour (0.05 CEUs) of continuing education credit. UAN: JA4008196-0000-20-128-H01-P
NCCN has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.50 AAPA Category 1 CME credit. Approval is valid until October 30, 2021. PAs should only claim credit commensurate with the extent of their participation.
- 0.50 AAPA Category 1 CME credit
- 0.50 ACPE contact hours
- 0.50 AMA PRA Category 1 Credit™
- 0.50 ANCC contact hours
- 0.50 Participation
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