Peripheral T-Cell Lymphomas-Not Otherwise Specified: A Shrinking Entity?
Peripheral T-cell lymphomas-not otherwise specified (PTCL-NOS) is now considered a heterogeneous group of distinct molecular subtypes with varied natural history and clinical outcome. Although the standard treatment approach remains the same for all subtypes of PTCL-NOS, these findings will have significant impact on the management of patients with PTCL-NOS as important evidence from clinical trials get translated into routine clinical practice. Accurate molecular subclassification of PTCL-NOS will be essential for the selection of appropriate treatment option based on the molecular subtype identified either by GEP or by immunohistochemistry. Informing hematologists and oncologists about these recent advances will improve their understanding of the pathogenesis of PTCL-NOS and help to guide how these strategies can be incorporated into routine practice when they become available for clinical use.
This information was originally presented at the NCCN 2020 Virtual Congress: Hematologic Malignancies™ held on October 9-10, 2020.
This educational program is designed to meet the educational needs of oncologists, hematologists, nurse practitioners, nurses, pharmacists, physician assistants, and other health care professionals who manage patients with hematologic malignancies.
Following this program, participants should be able to:
- Identify the different subtypes of peripheral T-cell lymphomas (PTCLs) included in the 2017 WHO Classification.
- Review the current treatment options and the rationale for the development of novel treatment options.
- Describe the molecular heterogeneity and its implications for the management of PTCL-not otherwise specified (PTCL-NOS).
Steven Horwitz, MD
Memorial Sloan Kettering Cancer Center
NCCN Medical Education Disclosure Policy
It is the policy of NCCN that every 12 months, all faculty, moderators, activity planners and all internal planning staff participating in NCCN continuing education activities are expected to disclose any financial relationships with a commercial interest as defined by the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support. In addition, all faculty presentations have been reviewed for adherence to the ACCME’s Standards for Commercial Support (the provider develops activities/educational interventions independent of commercial interests [SCS 1, 2 and 6] by experts on the topics).
Per the ACCME Standards for Commercial Support, individuals who do not disclose relevant financial relationships will be disqualified from involvement in the CE activity as a content developer, planner, or presenter. A complete list of individuals’ relationships with external entities is available upon request.
NCCN continuing education considers financial relationships to create a “conflict of interest” when an individual has both a financial relationship with a commercial interest and the opportunity to affect CE content about the products or services of a commercial interest with which he/she and/or a spouse or partner has a financial relationship.
NCCN continuing education considers “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. NCCN does not set a minimal dollar amount for relationships to be significant. Inherent in any amount is the incentive to maintain or increase the value of the relationship.
All faculty for this continuing education activity are competent in the subject matter and qualified by experience, training, and/or preparation for the tasks and methods of delivery.
Faculty presentations may include discussion of off-label use. Faculty will disclose that the use in question is not currently approved by the FDA per the product labeling.
The faculty listed below discloses the following relevant financial relationships:
Steven Horwitz, MD
ADC Therapeutics: Grant/Research Support
Aileron Therapeutics, Inc.: Grant/Research Support
Astex Pharmaceuticals: Consulting Fee
C4 Therapeutics: Consulting Fee
Celgene Corporation: Consulting Fee; Grant/Research Support
Corvus Pharmaceuticals: Grant/Research Support
Daiichi-Sankyo Co.: Grant/Research Support
Forty Seven, Inc.: Grant/Research Support
Janssen Pharmaceutica Products, LP: Consulting Fee
Kura Oncology, Inc.: Consulting Fee
Kyowa Hakko Kirin Co., Ltd.: Consulting Fee
Myeloid Therapeutics: Consulting Fee
Portola Pharmaceuticals, Inc.: Grant/Research Support
Seattle Genetics, Inc.: Consulting Fee; Grant/Research Support
Takeda Pharmaceuticals North America, Inc.: Consulting Fee
Trillium Therapeutics Inc.: Grant/Research Support
Verastem Oncology: Consulting Fee; Grant/Research Support
NCCN Staff Disclosures
The NCCN Activity Planning staff listed below discloses no relevant financial relationships:
Michael Abrams; Melissa Esplen; Mark A. Geisler; Kristina M. Gregory, RN, MSN, OCN; Kristin Kline Hasson; Rose Joyce; Karen Kanefield; Lisa Perfidio, MS; Shannon Ryan, CMP; Kathy Ann Smith, CHCP; Sarah Weinstein
The NCCN Leadership listed below discloses no relevant financial relationships:
Robert W. Carlson, MD; Gary J. Weyhmuller, MBA, SPHR
The NCCN Leadership listed below discloses the following relevant financial relationships:
Wui-Jin Koh, MD: IBM Watson Health for Oncology and Genomics; Scientific Advisor
The NCCN Clinical staff listed below discloses no relevant financial relationships:
Mary A. Dwyer, MS, CGC; Hema Sundar, PhD
In support of improving patient care, National Comprehensive Cancer Network (NCCN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
NCCN designates this live activity for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
NCCN designates this educational activity for a maximum of 0.50 contact hour.
NCCN designates this application-based continuing education activity for 0.50 contact hour (0.05 CEUs) of continuing education credit. UAN: JA4008196-0000-20-108-H01-P
NCCN has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.50 AAPA Category 1 CME credit. Approval is valid until October 30, 2021. PAs should only claim credit commensurate with the extent of their participation.
- 0.50 AAPA Category 1 CME credit
- 0.50 ACPE contact hours
- 0.50 AMA PRA Category 1 Credit™
- 0.50 ANCC contact hours
- 0.50 Participation
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