Updates in the Management of CLL/SLL: Management of Relapsed/Refractory Disease and the Role of Minimal Residual Disease

The therapeutic landscape of chronic lymphocytic leukemia (CLL) has evolved significantly in recent years, and the use of targeted therapy with small molecule inhibitors in the first-line setting will significantly alter the management of relapsed/refractory disease. In addition to the several factors related to patient (age, performance status, and comorbid conditions) and disease (clinical stage, cytogenetic or molecular characteristics), the type of prior first-line therapy and the duration of remission to that therapy are the key considerations for the selection of treatment for patients with relapsed or refractory CLL. The measurement of MRD is emerging as important tool to assess treatment efficacy and determine the duration of treatment based on the nature of therapeutic agent used. There is a continuing need to educate hematologists and oncologists about the challenges and special considerations involved in the management of patients with CLL so that they can make informed clinical decisions and develop an individualized treatment plan for their patients.

Target Audience

The program is designed to meet the needs and improve the competence and performance of the interprofessional oncology care team, including physicians, nurse practitioners, nurses, physician assistants, pharmacists, and other relevant health care professionals who manage the care of patients with cancer.

Learning Objectives

Following this program, participants should be able to:

  • Review the treatment options for patients with relapsed or refractory CLL/SLL.
  • Discuss available evidence on sequencing therapy for patients with relapsed/refractory disease and develop an individualized treatment plan based on prior first-line therapy, disease-specific and patient-specific characteristics.
  • Describe the role of minimal residual disease (MRD) assessment and its implications on the management of patients with CLL/SLL.  
Additional information
Supporters: 

This activity is supported by educational grants from:

  • Abbott's molecular business
  • Adaptive Biotechnologies
  • AstraZeneca
  • BeiGene, Ltd.
  • Blueprint Medicines
  • Daiichi Sankyo
  • Deciphera Pharmaceuticals
  • Eisai
  • Exact Sciences
  • Genentech, a member of the Roche Group
  • Gilead Sciences
  • GlaxoSmithKline
  • GRAIL, Inc.
  • Ipsen Biopharmaceuticals, Inc.
  • Jazz Pharmaceuticals, Inc.
  • Pharmacyclics LLC, an AbbVie Company and Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC.
  • Lilly
  • Olympus Corporation of the Americas
  • Novartis
  • Pfizer
  • Puma Biotechnology
  • Seagen Inc. formerly Seattle Genetics
  • Taiho Oncology, Inc.
  • TeSera Therapeutics

This activity is supported by independent medical education grants from: 

  • Bristol Myers Squibb 
  • Illumina, Inc. 
  • Regeneron Pharmaceuticals, Inc and Sanofi Genzyme

This activity is supported by independent educational grants from:

  • AbbVie
  • Astellas
  • Boehringer Ingelheim Pharmaceuticals, Inc.
  • Incyte
  • Merck & Co., Inc.

This activity is supported by educational funding provided by Amgen.

This educational activity is supported by a medical education grant from Exelixis, Inc. & Karyopharm® Therapeutics.

This project has been made possible in part by a grant from Varian Medical Systems/Global Medical Education Grant Program.

Course summary
Available credit: 
  • 0.75 AAPA Category 1 CME credit
  • 0.75 ACPE contact hours
  • 0.75 AMA PRA Category 1 Credit™
  • 0.75 ANCC contact hours
  • 0.75 Participation
Course opens: 
05/20/2021
Course expires: 
03/01/2022
Cost:
$0.00

Jennifer R. Brown, MD, PhD
Dana-Farber Cancer Institute

 

NCCN Continuing Education Disclosure Policy

It is the policy of NCCN that every 12 months, all faculty, moderators, activity planners and all internal planning staff participating in NCCN continuing education activities are expected to disclose any financial relationships with a commercial interest. In addition, all faculty presentations have been reviewed to ensure education is fair and balanced and that clinical content presented supports safe, effective patient care.  Individuals who do not disclose relevant financial relationships will be disqualified from involvement in the CE activity as a content developer, planner, or presenter. 

Definitions  

NCCN continuing education considers financial relationships to create a conflict of interest when an individual has both a financial relationship with a commercial interest and the opportunity to affect continuing education content about the products or services of a commercial interest with which he/she has a financial relationship.

NCCN continuing education considers relevant financial relationships as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. NCCN does not set a minimal dollar amount for relationships to be significant. Inherent in any amount is the incentive to maintain or increase the value of the relationship. 

Faculty Disclaimers

All faculty for this continuing education activity are competent in the subject matter and qualified by experience, training, and/or preparation for the tasks and methods of delivery.

Faculty presentations may include discussion of off-label use. Faculty will disclose that the use in question is not currently approved by the FDA per the product labeling.

Faculty Disclosures

The faculty listed below discloses the following relevant financial relationships: 

Jennifer R. Brown, MD, PhD
AbbVie, Inc.: Consulting Fee
Acerta Pharmaceuticals LP: Consulting Fee
AstraZeneca Pharmaceuticals LP: Consulting Fee
BeiGene: Consulting Fee
Catapult Therapeutics: Consulting Fee
Eli Lilly and Company: Consulting Fee
Genentech, Inc.: Consulting Fee
Juno Therapeutics, Inc./Celgene Corporation: Consulting Fee
Loxo Oncology, Inc.: Grant/Research Support
MEI Pharma Inc.: Consulting Fee
MorphoSys AG: Other Financial Benefit
Novartis Pharmaceuticals Corporation: Consulting Fee
Pfizer Inc.: Consulting Fee
Rigel Pharmaceuticals, Inc.: Consulting Fee
TG Therapeutics: Grant/Research Support
Verastem, Inc.: Grant/Research Support

Moderator Disclosures

The faculty listed below discloses the following relevant financial relationships:

Tanya Siddiqi, MD
AstraZeneca Pharmaceuticals LP: Scientific Advisor; Product/Speakers Bureau
BeiGene: Scientific Advisor
Bristol-Myers Squibb Company: Scientific Advisor
Celgene Corporation: Scientific Advisor
Janssen Pharmaceutical Products, LP: Product/Speakers Bureau
Juno Therapeutics, Inc.: Scientific Advisor
Kite Pharma: Scientific Advisor
Pharmacyclics: Product/Speakers Bureau
ResearchToPractice: Other Financial Benefit 

NCCN Staff Disclosures

The NCCN Leadership listed below discloses no relevant financial relationships:

Robert W. Carlson, MD; Wui-Jin Koh, MD; Gary J. Weyhmuller, MBA, SPHR

The NCCN Activity Planning staff listed below discloses no relevant financial relationships:

Mike Abrams; Melissa Esplen; Mark A. Geisler; Kristina M. Gregory, RN, MSN, OCN; Kristin Kline Hasson; Rose Joyce; Karen Kanefield; Lisa Perfidio, MS; Shannon Ryan, CMP; Kathy Ann Smith, CHCP; Sarah Weinstein

The NCCN Clinical staff listed below discloses no relevant financial relationships:

Mary A. Dwyer, MS, CGC; Hema Sundar, PhD

In support of improving patient care, National Comprehensive Cancer Network (NCCN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians
NCCN designates this live activity for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses
NCCN designates this educational activity for a maximum of 0.75 contact hour.

Pharmacists
NCCN designates this application-based continuing education activity for 0.75 contact hour (0.075 CEUs) of continuing education credit. UAN: JA4008196-0000-21-069-H01-P

Physician Assistants 
NCCN has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.75 AAPA Category 1 CME credit. Approval is valid until March 1, 2022. PAs should only claim credit commensurate with the extent of their participation.

Available Credit

  • 0.75 AAPA Category 1 CME credit
  • 0.75 ACPE contact hours
  • 0.75 AMA PRA Category 1 Credit™
  • 0.75 ANCC contact hours
  • 0.75 Participation

Price

Cost:
$0.00
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Required Hardware/software

To complete this activity, users will need:

  • A device with an Internet connection and sound playback capability
    • One of the two latest versions of Google Chrome, Mozilla Firefox, or Safari
    • Internet Explorer is no longer supported
  • Adobe Reader or other PDF reader software for certificate viewing/printing