Use of PARP Inhibitors for Ovarian Cancer

The data on poly(adenosine diphosphate-ribose) polymerase inhibitors (PARP inhibitors) for treatment of ovarian, primary peritoneal, or fallopian tube cancers has led to substantial changes in the recommendations for molecular testing, maintenance after first-line therapy, recurrence therapy, and maintenance after recurrence therapy. In multiple settings PARP inhibitors appear to provide clinical benefit across a wide range of patient groups, including patients with poor prognostic factors, and results seem to imply that there are a really wide range of patients and settings where it may be worth considering PARP inhibitor therapy. However, since extent of benefit from PARP inhibitor therapy appears to be dependent on the BRCA1/2 mutation status, HRD, and in some settings, loss of heterozygosity (LOH), and since there is currently very little data on the effect of PARP inhibitors in patients who have already been treated with these agents, it is important to discuss with patients potential approaches for maximizing their potential benefit from these agents, and set realistic expectations depending on what is known about the relationship between disease characteristics and likelihood of clinical benefit.

Target Audience

The program is designed to meet the needs and improve the competence and performance of the interprofessional oncology care team, including physicians, nurse practitioners, nurses, physician assistants, pharmacists, and other relevant health care professionals who manage the care of patients with cancer.

Learning Objectives

Following this program, participants should be able to:

  • Describe data from PARP inhibitor trials in patients with newly-diagnosed advanced ovarian cancer, and discuss how it may inform treatment and molecular testing in this setting.
  • Review factors that may impact the extent of clinical benefit from PARP inhibitor therapy.
  • Compare and contrast considerations for selecting recurrence therapy in patients who have progressed/recurred on or after PARPi maintenance.
Additional information
Supporters: 

This activity is supported by educational grants from:

  • Abbott's molecular business
  • Adaptive Biotechnologies
  • AstraZeneca
  • BeiGene, Ltd.
  • Blueprint Medicines
  • Daiichi Sankyo
  • Deciphera Pharmaceuticals
  • Eisai
  • Exact Sciences
  • Genentech, a member of the Roche Group
  • Gilead Sciences
  • GlaxoSmithKline
  • GRAIL, Inc.
  • Ipsen Biopharmaceuticals, Inc.
  • Jazz Pharmaceuticals, Inc.
  • Pharmacyclics LLC, an AbbVie Company and Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC.
  • Lilly
  • Olympus Corporation of the Americas
  • Novartis
  • Pfizer
  • Puma Biotechnology
  • Seagen Inc. formerly Seattle Genetics
  • Taiho Oncology, Inc.
  • TeSera Therapeutics

This activity is supported by independent medical education grants from: 

  • Bristol Myers Squibb 
  • Illumina, Inc. 
  • Regeneron Pharmaceuticals, Inc and Sanofi Genzyme

This activity is supported by independent educational grants from:

  • AbbVie
  • Astellas
  • Boehringer Ingelheim Pharmaceuticals, Inc.
  • Incyte
  • Merck & Co., Inc.

This activity is supported by educational funding provided by Amgen.

This educational activity is supported by a medical education grant from Exelixis, Inc. & Karyopharm® Therapeutics.

This project has been made possible in part by a grant from Varian Medical Systems/Global Medical Education Grant Program.

Course summary
Available credit: 
  • 0.75 AAPA Category 1 CME credit
  • 0.75 ACPE contact hours
  • 0.75 AMA PRA Category 1 Credit™
  • 0.75 ANCC contact hours
  • 0.75 Participation
Course opens: 
05/20/2021
Course expires: 
03/01/2022
Cost:
$0.00

Deborah K. Armstrong, MD
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

 

NCCN Continuing Education Disclosure Policy

It is the policy of NCCN that every 12 months, all faculty, moderators, activity planners and all internal planning staff participating in NCCN continuing education activities are expected to disclose any financial relationships with a commercial interest. In addition, all faculty presentations have been reviewed to ensure education is fair and balanced and that clinical content presented supports safe, effective patient care.  Individuals who do not disclose relevant financial relationships will be disqualified from involvement in the CE activity as a content developer, planner, or presenter. 

Definitions  

NCCN continuing education considers financial relationships to create a conflict of interest when an individual has both a financial relationship with a commercial interest and the opportunity to affect continuing education content about the products or services of a commercial interest with which he/she has a financial relationship.

NCCN continuing education considers relevant financial relationships as financial relationships in any amount occurring within the past 12 months that create a conflict of interest. NCCN does not set a minimal dollar amount for relationships to be significant. Inherent in any amount is the incentive to maintain or increase the value of the relationship. 

Faculty Disclaimers

All faculty for this continuing education activity are competent in the subject matter and qualified by experience, training, and/or preparation for the tasks and methods of delivery.

Faculty presentations may include discussion of off-label use. Faculty will disclose that the use in question is not currently approved by the FDA per the product labeling.

Faculty Disclosures

The faculty listed below discloses the following relevant financial relationships: 

Deborah K. Armstrong, MD
AbbVie, Inc.: Scientific Advisor
AstraZeneca Pharmaceuticals LP: Grant/Research Support
Clovis Oncology: Grant/Research Support
Eisai Inc.: Grant/Research Support
Pfizer Inc.: Grant/Research Support
Syndax Pharmaceuticals Inc.: Grant/Research Support 

Moderator Disclosures

The faculty listed below discloses the following relevant financial relationships:

Lainie Martin, MD
Elucida Oncology, Inc.: Scientific Advisor
SUTRO Biopharma, Inc.: Scientific Advisor

NCCN Staff Disclosures

The NCCN Leadership listed below discloses no relevant financial relationships:

Robert W. Carlson, MD; Wui-Jin Koh, MD; Gary J. Weyhmuller, MBA, SPHR

The NCCN Activity Planning staff listed below discloses no relevant financial relationships:

Mike Abrams; Melissa Esplen; Mark A. Geisler; Kristina M. Gregory, RN, MSN, OCN; Kristin Kline Hasson; Rose Joyce; Karen Kanefield; Lisa Perfidio, MS; Shannon Ryan, CMP; Kathy Ann Smith, CHCP; Sarah Weinstein

The NCCN Clinical staff listed below discloses no relevant financial relationships:

Jennifer L. Burns, BS; Anita M. Engh, PhD; Miranda Hughes, PhD

In support of improving patient care, National Comprehensive Cancer Network (NCCN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians
NCCN designates this live activity for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses
NCCN designates this educational activity for a maximum of 0.75 contact hour.

Pharmacists
NCCN designates this application-based continuing education activity for 0.75 contact hour (0.075 CEUs) of continuing education credit. UAN: JA4008196-0000-21-071-H01-P

Physician Assistants 
NCCN has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.75 AAPA Category 1 CME credit. Approval is valid until March 1, 2022. PAs should only claim credit commensurate with the extent of their participation.

Available Credit

  • 0.75 AAPA Category 1 CME credit
  • 0.75 ACPE contact hours
  • 0.75 AMA PRA Category 1 Credit™
  • 0.75 ANCC contact hours
  • 0.75 Participation

Price

Cost:
$0.00
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Required Hardware/software

To complete this activity, users will need:

  • A device with an Internet connection and sound playback capability
    • One of the two latest versions of Google Chrome, Mozilla Firefox, or Safari
    • Internet Explorer is no longer supported
  • Adobe Reader or other PDF reader software for certificate viewing/printing