NCCN Guidelines® Insights - Bladder Cancer, Version 2.2022
The NCCN Guidelines for Bladder Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with bladder cancer and other urinary tract cancers (upper tract tumors, urothelial carcinoma of the prostate, primary carcinoma of the urethra). These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guidelines regarding the treatment of non–muscle-invasive bladder cancer, including how to treat in the event of a bacillus Calmette-Guérin (BCG) shortage; new roles for immune checkpoint inhibitors in non–muscle-invasive, muscle-invasive, and metastatic bladder cancer; and the addition of antibody–drug conjugates for metastatic bladder cancer.
This activity is designed to meet the educational needs of oncologists, nurses, pharmacists, and other health care professionals who manage patients with cancer.
Upon completion of this activity, participants will be able to:
- Integrate into professional practice the updates to the NCCN Guidelines for Bladder Cancer
- Describe the rationale behind the decision-making process for developing the NCCN Guidelines for Bladder Cancer
NCCN Continuing Education Disclosure Policy
It is the policy of NCCN that all planners, faculty, moderators, authors, reviewers and anyone involved in the planning and delivery of NCCN continuing education activities are expected to disclose ALL financial relationships they have had in the past 24 months with ineligible companies. The ACCME Standards for Integrity and Independence require that individuals who refuse to provide this information will be disqualified from involvement in the planning and implementation of accredited continuing education presented by NCCN. NCCN identifies, mitigates and discloses to learners all relevant financial relationships.
In addition, all content has been reviewed to ensure education promotes safe, effective patient care and does not promote the products or services of an ineligible company. Content, including any presentation of therapeutic options, is fair, balanced, evidence-based, scientifically accurate, and free of commercial bias and marketing.
Ineligible Company: An ineligible company is any entity whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
Relevant Financial Relationships: Financial relationships of any dollar amount occurring within the past 24 months are defined as relevant if the educational content an individual can control is related to the business lines or products of an ineligible company. There is no minimum financial threshold. We ask for disclosure of ALL financial relationships with ineligible companies, regardless of the amount and regardless of the potential relevance of each relationship to the education.
All faculty for this continuing education activity are competent in the subject matter and qualified by experience, training, and/or preparation for the tasks and methods of delivery.
Faculty presentations may include discussion of off-label use. Faculty will disclose that the use in question is not currently approved by the FDA per the product labeling or marketing.
Individuals Who Provided Content Development and/or Authorship Assistance
The faculty listed below have no relevant financial relationships with ineligible companies to disclose.
Philippe E. Spiess, MD, MS, Panel Vice Chair
Rick C. Bangs, MBA, PMP, Patient Advocate
Lisa Gurski, PhD, Manager, Licensed Clinical Content, NCCN
Mary Dwyer, MS, Sr. Director, Guidelines Operations, NCCN
Carly J. Cassara, MSc, Guidelines Layout Specialist, NCCN
The faculty listed below have the following relevant financial relationships with ineligible companies to disclose. All of the relevant financial relationships listed for these individuals have been mitigated.
Thomas W. Flaig, MD, Panel Chair, has disclosed receiving grant/research support from Agensys, Inc., Astellas Pharma US, Inc., AstraZeneca Pharmaceuticals, LP, Bristol-Myers Squibb Company, Genentech, Inc., Janssen Pharmaceutica Products, LP, Merck & Co., Inc., sanofi-aventis U.S., and Seattle Genetics, Inc.; serving as scientific advisor for Janssen Pharmaceutica Products, LP, and Seattle Genetics, Inc.; having equity interest/stock options in Aurora Oncology; and licensing intellectual property rights to Aurora Oncology.
Ronac Mamtani, MD, MSCE, Panel Member, has disclosed receiving grant/research support from Astellas Pharma US, Inc., and Merck & Co., Inc.; and receiving consulting fees from Bristol-Myers Squibb Company, and Seagen Inc.
Mamta Parikh, MD, MS, Panel Member, has disclosed receiving consulting fees from AstraZeneca Pharmaceuticals LP, Exelixis Inc., and OncoCyte Corporation; and receiving grant/research support from Karyopharm Therapeutics.
Elizabeth R. Plimack, MD, MS, Panel Member, has disclosed receiving consulting fees from Astellas Pharma US, Inc., AstraZeneca Pharmaceuticals LP, AVEO Pharmaceuticals, Inc., Bristol-Myers Squibb Company, Calithera Biosciences, Inc., EMD Serono, Exelixis Inc., IMV Inc., Janssen Pharmaceutica Products, LP, MEI Pharma Inc., Merck & Co., Inc., Natera, Inc., Pfizer Inc., Regeneron Pharmaceuticals, and Seattle Genetics, Inc.
NCCN Staff Disclosures
None of the planners for this educational activity have relevant financial relationships to disclose with ineligible companies whose primary business is producing, marketing, selling, reselling, or distributing healthcare products used by or on patients.
In support of improving patient care, National Comprehensive Cancer Network (NCCN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
NCCN designates this journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
NCCN designates this educational activity for a maximum of 1.0 contact hour.
NCCN designates this knowledge-based continuing education activity for 1.0 contact hour (0.1 CEUs) of continuing education credit. UAN: JA4008196-0000-22-008-H01-P
NCCN has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credit. Approval is valid until August 10, 2023. PAs should only claim credit commensurate with the extent of their participation.
- 1.00 AAPA Category 1 CME credit
- 1.00 ACPE contact hours
- 1.00 AMA PRA Category 1 Credit™
- 1.00 ANCC contact hours
- 1.00 Participation