Monthly Oncology Tumor Boards: B-Cell Lymphomas: Histologic Transformation of Indolent Lymphomas
Precise diagnosis of histologic transformation is essential since the prognosis and management of transformed indolent lymphoma is significantly different from that of its indolent counterpart. Treatment should be highly individualized taking into account the histology of aggressive lymphoma at the time of transformation (DLBCL vs. HGBL), prior treatment received for underlying indolent lymphoma follicular lymphoma versus marginal zone lymphomas (FL vs. MZL), and the patient’s eligibility for transplant. Educating clinicians about the challenges associated with the management of transformed indolent lymphomas and the recent advances in management would help clinicians to incorporate novel therapies into routine clinical practice in the appropriate patient population to improve clinical outcomes.
Target Audience
This activity is designed to meet the educational needs of physicians/oncologists, nurse practitioners, nurses, physician assistants, pharmacists, and other health care professionals who manage patients with cancer.
Learning Objectives
Following this activity, participants should be able to:
- Identify the risk factors associated with the histologic transformation of indolent B-cell lymphomas.
- Review evidence from clinical trials supporting the use of novel treatment options for transformed indolent B-cell lymphomas.
- Develop an individualized treatment plan for patients with transformed indolent B-cell lymphomas.
Paolo F. Caimi, MD
Case Comprehensive Cancer Center/
Cleveland Clinic Taussig Cancer Institute
Sarah Ondrejka, DO
Case Comprehensive Cancer Center/
Cleveland Clinic Taussig Cancer Institute
Allison Winter, MD
Case Comprehensive Cancer Center/
Cleveland Clinic Taussig Cancer Institute
NCCN Continuing Education Disclosure Policy
It is the policy of NCCN that all planners, faculty, moderators, authors, reviewers and anyone involved in the planning and delivery of NCCN continuing education activities are expected to disclose ALL financial relationships they have had in the past 24 months with ineligible companies. The ACCME Standards for Integrity and Independence require that individuals who refuse to provide this information will be disqualified from involvement in the planning and implementation of accredited continuing education presented by NCCN. NCCN identifies, mitigates and discloses to learners all relevant financial relationships.
In addition, all content has been reviewed to ensure education promotes safe, effective patient care and does not promote the products or services of an ineligible company. Content, including any presentation of therapeutic options, is fair, balanced, evidence-based, scientifically accurate, and free of commercial bias and marketing.
Definitions
Ineligible Company: An ineligible company is any entity whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
Relevant Financial Relationships: Financial relationships of any dollar amount occurring within the past 24 months are defined as relevant if the educational content an individual can control is related to the business lines or products of an ineligible company. There is no minimum financial threshold. We ask for disclosure of ALL financial relationships with ineligible companies, regardless of the amount and regardless of the potential relevance of each relationship to the education.
Faculty Disclaimers
All faculty for this continuing education activity are competent in the subject matter and qualified by experience, training, and/or preparation for the tasks and methods of delivery.
Faculty presentations may include discussion of off-label use. Faculty will disclose that the use in question is not currently approved by the FDA per the product labeling or marketing.
Faculty Disclosures
The faculty listed below have no financial relationships with ineligible companies to disclose.
Sarah Ondrejka, DO
The faculty listed below have the following relevant financial relationship(s) with ineligible companies to disclose. All of the relevant financial relationships listed for these individuals have been mitigated.
Paolo F. Caimi, MD
AbbVie, Inc.: Consulting Fee
ADC Therapeutics: Scientific Advisor
Arvinas, Inc.: Consulting Fee
Bristol Myers Squibb: Scientific Advisor
Kite/Gilead: Consulting Fee
Novartis Pharmaceuticals Corporation: Scientific Advisor
SOBI: Consulting Fee
Synthekine: Scientific Advisor
Allison Winter, MD
ADC Therapeutics SA: Consulting Fee
AstraZeneca Pharmaceuticals LP: Consulting Fee
BeiGene: Consulting Fee
Curio Science: Honoraria
NCCN Staff Disclosures
None of the planners for this educational activity have relevant financial relationships to disclose with ineligible companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
In support of improving patient care, National Comprehensive Cancer Network (NCCN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Physicians
NCCN designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nurses
NCCN designates this educational activity for a maximum of 1.0 contact hour.
Pharmacists
NCCN designates this knowledge-based continuing education activity for 1.0 contact hour (0.10 CEUs) of continuing education credit. UAN: JA4008196-0000-24-037-L01-P
Physician Assistants
NCCN has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credit. PAs should only claim credit commensurate with the extent of their participation.
Case Managers
This program has been pre-approved by The Commission for Case Manager Certification to provide continuing education credit to CCM® board certified case managers. The course is approved for 1 CE contact hour. Activity Code: I00059514; Approval #: 240001584
Available Credit
- 1.00 AAPA Category 1 CME credit
- 1.00 AMA PRA Category 1 Credit™
- 1.00 ANCC contact hours
- 1.00 CCM clock hours
- 1.00 Participation
Price
This webinar was presented live one time only on Wednesday, May 29, 2024, from 2:30 PM – 3:30 PM EDT (UTC -4).
The recorded activity is available here.
NCCN Non-Discrimination/Harassment Policy – Affiliated Persons and Volunteers
NCCN is committed to providing workplaces and events that are free from discrimination or harassment of any kind for all participants, and has a zero-tolerance policy for any such conduct. NCCN requires individuals participating on NCCN Guidelines Panels, standing and ad hoc committees, meetings and seminars, or other NCCN-affiliated activities and events to adhere to this policy.
To access this policy including reporting procedures, please visit NCCN.org/non-discrimination.
Required Hardware/software
To complete this activity, users will need:
- A device with an Internet connection and sound playback capability
- One of the two latest versions of Google Chrome, Mozilla Firefox, or Safari
- Internet Explorer is no longer supported
- Adobe Reader or other PDF reader software for certificate viewing/printing