Cancer Risk Reduction Strategies for Transgender, Non-Binary, and Gender Diverse People with Hereditary Cancer Syndromes

Transgender, non-binary, and gender diverse populations with hereditary cancer syndromes experience unique challenges over the course of their cancer care, particularly with regards to screening, surveillance, and risk reducing procedures. This is in part due to a lack of data from clinical trials and national registries to inform care. Education is needed at all levels of the health care system to aid providers in making the most informed possible decisions in caring for this patient population. 

Target Audience

This educational program is designed to meet the educational needs of physicians/oncologists, nurse practitioners, nurses, PAs, pharmacists, social workers, and other health care professionals who manage patients with cancer.

Learning Objectives

Following this program, participants should be able to:

  • Review the challenges faced by the transgender, non-binary, and gender diverse population during cancer diagnosis, surveillance, and treatment.
  • Discuss gender affirming hormone therapies and their potential effect on cancer risks in transgender, non-binary, and gender diverse individuals with hereditary cancer syndromes.
  • Identify possible cancer screening and risk-reducing strategies for patients in this population who have hereditary cancer syndromes.
Additional information

Supported by educational grants from AstraZeneca; Coherus BioSciences; Dendreon Pharmaceuticals LLC; Eisai; Exact Sciences; Genentech, a member of the Roche Group; GRAIL, LLC; GSK; Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC; Lilly; Menarini-Stemline; Novartis; Novocure; Olympus Corporation of the Americas; Sanofi; Sirtex; and Taiho Oncology, Inc. Supported by independent educational grants from Daiichi Sankyo; Incyte Corporation; and Merck & Co., Inc., Rahway, NJ, USA. Supported by independent medical education grants from Boehringer Ingelheim Pharmaceuticals, Inc. and Regeneron Pharmaceuticals, Inc. Supported by a grant from Pfizer Inc. Supported by a medical education grant from Karyopharm Therapeutics. This project has been made possible in part by a grant from Varian Medical Systems, a Siemens Healthineers company/Global Medical Education Grant Program.

Course summary
Available credit: 
  • 1.00 AAPA Category 1 CME credit
  • 1.00 ACPE contact hours
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 ANCC contact hours
  • 1.00 ASWB continuing education credit
  • 1.00 Participation
Course opens: 
Course expires: 

Julie S. Mak, MS, MSc, CGC
UCSF Helen Diller Family Comprehensive Cancer Center

Diego Rodriguez, MSN, RN, OCN
City of Hope National Medical Center


NCCN Continuing Education Disclosure Policy

It is the policy of NCCN that all planners, faculty, moderators, authors, reviewers and anyone involved in the planning and delivery of NCCN continuing education activities are expected to disclose ALL financial relationships they have had in the past 24 months with ineligible companies. The ACCME Standards for Integrity and Independence require that individuals who refuse to provide this information will be disqualified from involvement in the planning and implementation of accredited continuing education presented by NCCN. NCCN identifies, mitigates and discloses to learners all relevant financial relationships.

In addition, all content has been reviewed to ensure education promotes safe, effective patient care and does not promote the products or services of an ineligible company. Content, including any presentation of therapeutic options, is fair, balanced, evidence-based, scientifically accurate, and free of commercial bias and marketing. 


Ineligible Company: An ineligible company is any entity whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. 

Relevant Financial Relationships: Financial relationships of any dollar amount occurring within the past 24 months are defined as relevant if the educational content an individual can control is related to the business lines or products of an ineligible company. There is no minimum financial threshold. We ask for disclosure of ALL financial relationships with ineligible companies, regardless of the amount and regardless of the potential relevance of each relationship to the education.

Faculty Disclaimers

All faculty for this continuing education activity are competent in the subject matter and qualified by experience, training, and/or preparation for the tasks and methods of delivery.

Faculty presentations may include discussion of off-label use. Faculty will disclose that the use in question is not currently approved by the FDA per the product labeling or marketing.

Faculty Disclosures

The faculty listed below have no relevant financial relationships with ineligible companies to disclose.

Julie S. Mak, MS, MSc, CGC
Diego Rodriguez, MSN, RN, OCN

NCCN Staff Disclosures

The planner listed below has the following relevant financial relationships with ineligible companies to disclose.  All of the relevant financial relationships listed for these individuals have been mitigated.

Crystal Denlinger, MD, FACP 
2seventy bio: Grant/Research Support
AbbVie, Inc.: Grant/Research Support
Bluebird bio: Grant/Research Support
Bristol Myers Squibb: Grant/Research Support
Eli Lilly and Company: Grant/Research Support
Genentech, Inc: Grant/Research Support
GSK: Grant/Research Support
Pfizer Inc: Grant/Research Support
sanofi-aventis U.S.: Grant/Research Support

None of the other planners for this educational activity have relevant financial relationships to disclose with ineligible companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.


In support of improving patient care, National Comprehensive Cancer Network (NCCN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

NCCN designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

NCCN designates this educational activity for a maximum of 1.0 contact hour.

NCCN designates this knowledge-based continuing education activity for 1.0 contact hour (0.10 CEUs) of continuing education credit. UAN: JA4008196-0000-24-055-H01-P

NCCN has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credit. Approval is valid until March 1, 2025. PAs should only claim credit commensurate with the extent of their participation.

Social Workers
As a Jointly Accredited Organization, NCCN is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit. NCCN maintains responsibility for this course. Social workers completing this course receive 1.0 continuing education credit.

Available Credit

  • 1.00 AAPA Category 1 CME credit
  • 1.00 ACPE contact hours
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 ANCC contact hours
  • 1.00 ASWB continuing education credit
  • 1.00 Participation


Please login or register to take this course.

Required Hardware/software

To complete this activity, users will need:

  • A device with an Internet connection and sound playback capability
    • One of the two latest versions of Google Chrome, Mozilla Firefox, or Safari
    • Internet Explorer is no longer supported
  • Adobe Reader or other PDF reader software for certificate viewing/printing