Recorded Presentation from the NCCN Pharmacy Updates: What Grade Are You In? The Role of Targeted Therapy in Pediatric Diffuse High-Grade Gliomas
Targeted therapy is a relatively novel treatment approach to pediatric high-grade gliomas. Identifying specific molecular targets with correspondingly effective agents substantially benefits the treatment landscape and broadens therapeutic options in both the adjuvant therapy and recurrent or progressive disease setting.
NCCN Pharmacy Updates: What Grade Are You In? The Role of Targeted Therapy in Pediatric Diffuse High-Grade Gliomas
Targeted therapy is a relatively novel treatment approach to pediatric high-grade gliomas. Identifying specific molecular targets with correspondingly effective agents substantially benefits the treatment landscape and broadens therapeutic options in both the adjuvant therapy and recurrent or progressive disease setting.
NCCN Guidelines® for Central Nervous System Cancers: Updates in the Treatment of Adult Patients with Glioma
With the use of genetic and molecular testing, gliomas can be differentiated more accurately in terms of prognosis and, in some instances, response to different therapies. The updated WHO classification of tumors of the central nervous system (CNS) takes into account the importance of molecular data for accurately diagnosing CNS tumors. Detection of genetic or epigenetic alterations could expand clinical trial options for a patient with a brain tumor.
Archived Monthly Oncology Tumor Boards: A Multidisciplinary Approach to Individualized Patient Care - Central Nervous System Cancers
Histopathologic and molecular characterization of high-grade gliomas should now be standard practice, as specific markers used to define molecular subgroups among some anaplastic gliomas have been shown to have prognostic value. However, there are currently no targeted agents that have shown efficacy in the treatment of glioblastoma. The differential benefit from concurrent versus adjuvant temozolomide in patients with anaplastic gliomas continues to be unclear.
Monthly Oncology Tumor Boards: A Multidisciplinary Approach to Individualized Patient Care - Central Nervous System Cancers
Histopathologic and molecular characterization of high-grade gliomas should now be standard practice, as specific markers used to define molecular subgroups among some anaplastic gliomas have been shown to have prognostic value. However, there are currently no targeted agents that have shown efficacy in the treatment of glioblastoma. The differential benefit from concurrent versus adjuvant temozolomide in patients with anaplastic gliomas continues to be unclear.
The Role of Molecular Pathology in Glioma Staging and Treatment of Anaplastic Gliomas

This information was originally presented at the NCCN 23rd Annual Conference: Improving the Quality, Effectiveness, and Efficiency of Cancer Care held in Orlando, Florida, from March 22 - 24, 2018.

Controversies in the Treatment of Elderly Patients With Newly Diagnosed Glioblastoma

Approximately half of all patients with glioblastoma are older than 65 years and nearly one-quarter are older than 70 years, with a rising incidence of this disease in the elderly population.

NCCN Task Force Report: Evaluating the Clinical Utility of Tumor Markers in Oncology

The molecular analysis of biomarkers in oncology is rapidly advancing, but the incorporation of new molecular tests into clinical practice will require a greater understanding of the genetic changes that drive malignancy, the assays used to measure the resulting phenotypes and genotypes, and the

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