With improvement in treatment options and supportive care, patients with multiple myeloma (MM) are living longer. The majority of patients with MM are at risk for osteolytic bone lesions, osteoporosis, and infections among other complications. The outcomes of patients with MM can be improved by effective management of infections; recognizing and managing side effects of bone modifying therapy; and implementing plans of care to promote health, safety, mobility, and overall improved quality of life.