While cytokine release syndrome and neurotoxicity are widely reported as the most common acute CAR T-cell toxicities, it is essential for providers to understand that CAR T-cell therapy may also result in other toxicities (such as infections, cytopenias, or B-cell aplasia), some of which could persist for months to years after infusion.

Bispecific T-cell engagers are emerging as promising treatment options for patients with heavily pretreated multiple myeloma and B-cell lymphomas, especially for patients with disease relapse following CAR T-cell therapy. Careful monitoring of adverse events and implementing appropriate supportive care strategies is important to maximize the clinical benefit associated with bispecific T-cell engager therapy.

Understanding optimal sequencing for patients with relapsed/refractory multiple myeloma can be a challenge in clinical practice. A uniform treatment approach cannot be applied to all patients. Physicians and other care providers must understand the evolving therapeutic options in the context of the patient's therapeutic and disease history to navigate through the complex treatment landscape.

In order to optimize overall patient outcomes, clinicians need to understand the evidence behind the current guidelines’ recommendations, the rationale for appropriate treatment selection, and the management of any treatment- or multiple myeloma-specific adverse events.

With careful risk assessment, monitoring, and prophylactic treatment, the cardiovascular adverse events associated with multiple myeloma (MM) treatments can be prevented or identified and managed at an early stage. To optimize the management of patients with multiple myeloma and cardiac comorbidities, it is important for clinicians to learn how to recognize these risks and implement appropriate management strategies.

Education about individualizing treatment strategies will assist healthcare providers to make informed decisions about incorporating immunotherapies into treatment regimens. 

Clinicians must understand the treatment evolution and guidelines for when to administer two-, three-, or four drug regimens as initial or subsequent therapy in context of the patient's therapeutic and disease history. In addition, it is important for clinicians to educate patients about their different treatment options (e.g., administration and adverse events) and discuss patient preferences and individual circumstances that may affect treatment recommendations.

In order to optimize overall patient outcomes, clinicians need to understand the evidence behind the current guidelines’ recommendations, the rationale for appropriate treatment selection, and the management of any treatment- or multiple myeloma-specific adverse events.

To navigate through the complex treatment landscape, physicians and other oncology care providers must understand the evolving therapeutic options and guidelines for administration of the available therapies in the context of the patient's therapeutic and disease history. The increasing complexity of myeloma treatment warrants rigorous efforts to provide adequate supportive care and preserve the quality of life of patients.

Pharmacists should be aware of the new data and recommendations surrounding this novel agent and how they relate to improvements in patient survival and quality of life. It is also important to be aware of the potential for unique and potentially severe adverse events that can occur with these therapies.