Monthly Oncology Tumor Boards: A Multidisciplinary Approach to Individualized Patient Care - Non-Melanoma Skin Cancer

November 13, 2019

Systemic Therapy for Advanced Merkel Cell Carcinoma (MCC)
Although there are no randomized comparative trials demonstrating superiority of checkpoint immunotherapy compared with chemotherapy, checkpoint immunotherapies provide response rates similar to those previously reported for chemotherapy, and may provide greater durability of response. Therefore, avelumab, nivolumab, and pembrolizumab are included as recommended systemic therapy options for treatment of disseminated disease, and use of cytotoxic therapies in this setting is discouraged unless the patient has contraindications to checkpoint immunotherapy or has experienced relapse or progression during or after previous treatment with checkpoint immunotherapy.  Avelumab is FDA approved for MCC and only one other cancer type, so clinical experience with this anti-PD-L1 agent is more limited than for other types of checkpoint inhibitors (targeting CTLA-4, PD-1), and clinicians may not be familiar with its safety profile. Clinician and patient education is critical for safe administration of checkpoint immunotherapies and screening to identify patients who are not suitable candidates for checkpoint inhibitor therapy.

Target Audience

This program is designed to meet the educational needs of physicians, nurses, pharmacists, and other health care professionals who manage patients with cancer.

Learning Objectives

Following this activity, participants should be able to:

  • Describe systemic therapy options for stage IV MCC, including patient selection criteria for each option.
  • List considerations for determining whether to attempt surgery, RT, systemic therapy combined modality approaches for disseminated MCC.
  • Describe the toxicity profile for avelumab and compare/contrast with safety profiles and recommended precautions for other checkpoint immunotherapies.
Additional information
Supporters: 

This activity is supported by an educational grant from:

  • AstraZeneca
  • Celgene Corporation
  • Clovis Oncology, Inc.
  • Eisai
  • Genomic Health, Inc.
  • Lilly
  • Novartis
  • Sanofi Genzyme
  • Taiho Oncology, Inc
  • TESARO

This activity is supported by an independent medical education grant from:

  • Advanced Accelerator Applications, a Novartis company
  • Bristol-Myers Squibb
  • Pharmacyclics LLC and Janssen

This activity is supported by an independent educational grant from:

  • AbbVie
  • Astellas and Pfizer, Inc.
  • Merck  & Co., Inc.

This activity is supported by a medical education grant from Exelixis, Inc.

This activity is supported by an unrestricted educational grant from Gilead Sciences, Medical Affairs.

Course summary
Available credit: 
  • 1.00 AAPA Category 1 CME credit
  • 1.00 ACPE contact hours
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 ANCC contact hours
  • 1.00 CCM clock hours
  • 1.00 Participation
Course opens: 
09/24/2019
Course expires: 
01/26/2020
Event starts: 
11/13/2019 - 3:00pm
Event ends: 
11/13/2019 - 4:00pm
Cost:
$0.00

Paul Nghiem, MD, PhD
Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance

Coley J. Doolittle-Amieva, PA-C
Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance

 

NCCN Medical Education Disclosure Policy
It is the policy of NCCN that every 12 months, all faculty, moderators, activity planners and all internal planning staff participating in NCCN continuing education activities are expected to disclose any financial relationships with a commercial interest as defined by the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support. In addition, all faculty presentations have been reviewed for adherence to the ACCME’s Standards for Commercial Support (the provider develops activities/educational interventions independent of commercial interests [SCS 1, 2 and 6] by experts on the topics). 

Per the ACCME Standards for Commercial Support, individuals who do not disclose relevant financial relationships will be disqualified from involvement in the CE activity as a content developer, planner, or presenter. A complete list of individuals’ relationships with external entities is available upon request.

Full disclosure of faculty relationships will be made prior to the activity.

In support of improving patient care, National Comprehensive Cancer Network (NCCN) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians
NCCN designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses
NCCN designates this educational activity for a maximum of 1.0 contact hour.

Pharmacists
NCCN designates this knowledge-based continuing education activity for 1.0 contact hour (0.10 CEUs) of continuing education credit. UAN: TBD

Physician Assistants 
NCCN has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.0 AAPA Category 1 CME credit. PAs should only claim credit commensurate with the extent of their participation.

Case Managers
This program has been pre-approved by The Commission for Case Manager Certification to provide continuing education credit to CCM® board certified case managers. Credit approval for case managers is pending for this program. 

Available Credit

  • 1.00 AAPA Category 1 CME credit
  • 1.00 ACPE contact hours
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 ANCC contact hours
  • 1.00 CCM clock hours
  • 1.00 Participation

Accreditation Period

Course opens: 
09/24/2019
Course expires: 
01/26/2020

Price

Cost:
$0.00
Please login or register to take this course.

Click the Take Course button to register for this live webinar.

This webinar will be presented live one time only on Wednesday, November 13, 2019, from 3:00 - 4:00 PM Eastern Standard Time (EDT) (UTC -5).  To adjust for other time zones, click here.

Required Hardware/software

To complete this activity, users will need:

  • A device with an Internet connection and sound playback capability
    • One of the two latest versions of Google Chrome, Mozilla Firefox, or Safari
    • Internet Explorer is no longer supported
  • Adobe Reader or other PDF reader software for certificate viewing/printing